Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367069 | 1.00 | TP53 (0.64) | TP53MAOAMAOBPOLBMAPT | |
| SCHEMBL3367007 | 0.90 | MAOA (0.62) | TP53MAOAMAOBPOLBMAPT | |
| SCHEMBL3366999 | 0.90 | MAOA (0.62) | TP53MAOAMAOBPOLBMAPT | |
| SCHEMBL3367241 | 0.89 | MAOB (0.80) | TP53MAOAMAOBPOLBMAPT | |
| SCHEMBL3367239 | 0.89 | MAOB (0.80) | TP53MAOAMAOBPOLBMAPT | |
| SCHEMBL3367693 | 0.87 | MAOA (0.78) | TP53MAOAMAOBPOLBMAPT | |
| SCHEMBL17383722 | 0.86 | POLB (0.61) | TP53POLBMAPTLMNAKMT2A | |
| SCHEMBL20887738 | 0.85 | KMT2A (0.50) | TP53MAOAMAOBMAPTLMNA | |
| SCHEMBL26104021 | 0.83 | POLB (0.54) | TP53MAOAMAOBPOLBMAPT | |
| SCHEMBL3367166 | 0.82 | LMNA (0.52) | TP53POLBMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542970-B1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| US-7151111-B2 | 4-pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-12-19 | — | — | US | disclosed |
| EP-1542970-A1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-06-22 | — | — | EP | disclosed |
| US-20040116707-A1 | 4-Pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-17 | — | — | US | disclosed |
| WO-2004026825-A1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |