SCHEMBL3368153

SCHEMBL3368153

COc1cccc(-c2nnc(C3CCCN3OC(=O)O)o2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 4/20 0.58
HCRTR2 O43614 4/20 0.58
ALDH1A1 P00352 2/20 0.50
USP30 Q70CQ3 1/20 0.48
TNKS O95271 1/20 0.47
PARP1 P09874 1/20 0.47
PARP2 Q9UGN5 1/20 0.47
KDM4E B2RXH2 2/20 0.47
MAPT P10636 2/20 0.46
LRRK2 Q5S007 1/20 0.46
NPC1 O15118 1/20 0.45
USP2 O75604 1/20 0.45
MAPK1 P28482 1/20 0.45
RAB9A P51151 1/20 0.45
HSD17B10 Q99714 1/20 0.45
POLB P06746 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.44
SCD5 Q86SK9 1/20 0.44
TSHR P16473 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3370373 0.86 USP30 (0.51) HCRTR1HCRTR2ALDH1A1USP30TNKS
SCHEMBL3368150 0.86 HCRTR1 (0.67) HCRTR1HCRTR2ALDH1A1USP30KDM4E
SCHEMBL3366782 0.84 USP30 (0.52) HCRTR1HCRTR2ALDH1A1USP30KDM4E
SCHEMBL3370622 0.82 TSHR (0.50) HCRTR1HCRTR2ALDH1A1TNKSPARP1
SCHEMBL3368239 0.81 ALDH1A1 (0.56) HCRTR1HCRTR2ALDH1A1USP30TNKS
SCHEMBL3367915 0.80 HCRTR1 (0.62) HCRTR1HCRTR2ALDH1A1TNKSPARP1
SCHEMBL3369692 0.79 HCRTR1 (0.59) HCRTR1HCRTR2ALDH1A1USP30TNKS
SCHEMBL3366784 0.78 HCRTR1 (0.65) HCRTR1HCRTR2SCD5
SCHEMBL3366720 0.78 HCRTR1 (0.65) HCRTR1HCRTR2ALDH1A1KDM4ENPC1
SCHEMBL3367057 0.78 HCRTR1 (0.65) HCRTR1HCRTR2ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1532141-B1 2-PYRROLIDIN-2-YL- [1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS GRUENENTHAL GMBH (DE) 2010-10-13 EP disclosed