Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALML3 | P27482 | 6/20 | 0.52 |
| ▸ | MAOA | P21397 | 11/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368958 | 1.00 | CALML3 (0.52) | CALML3MAOAMAOBCYP2C19CYP2C9 | |
| SCHEMBL3368955 | 1.00 | CALML3 (0.52) | CALML3MAOAMAOBCYP2C19CYP2C9 | |
| SCHEMBL3372083 | 0.87 | MAOA (0.56) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL13711498 | 0.87 | MAOA (0.56) | CALML3MAOAMAOBCYP2C19CYP3A4 | |
| SCHEMBL13711610 | 0.86 | MAOA (0.57) | CALML3MAOAMAOBCYP2C19CYP2C9 | |
| SCHEMBL13711613 | 0.86 | MAOB (0.54) | CALML3MAOAMAOBCYP2C19CYP2C9 | |
| SCHEMBL3368176 | 0.86 | MAOA (0.53) | CALML3MAOACYP2C9CYP3A4 | |
| SCHEMBL3367145 | 0.86 | MAOB (0.54) | CALML3MAOAMAOBCYP2C19CYP2C9 | |
| SCHEMBL3368656 | 0.86 | MAOA (0.47) | CALML3MAOAMAOBCYP2C19CYP2C9 | |
| SCHEMBL3368721 | 0.86 | CALML3 (0.46) | CALML3MAOAMAOBCYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646629-B1 | CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK SHARP & DOHME (US) | 2010-06-23 | — | — | EP | disclosed |
| US-7582659-B2 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK & CO., INC. (US) | 2009-09-01 | — | — | US | disclosed |
| US-7462633-B2 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK & CO., INC. (US) | 2008-12-09 | — | — | US | disclosed |
| US-20070203187-A1 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK & CO., INC. (US) | 2007-08-30 | — | — | US | disclosed |
| US-20050038092-A1 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | MERCK SHARP & DOHME CORP. | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203187-A1 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | OXA1L, ALAD, COASY | CALML3 3370/4885MAOA 2977/4885MAOB 1835/4885 |
| US-20050038092-A1 | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof | OXA1L, ALAD, COASY | CALML3 3370/4885MAOA 2977/4885MAOB 1835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.