Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661501 | 0.91 | CYP1A2 (0.49) | TSHRNPSR1MEN1KMT2AHPGD | |
| SCHEMBL664081 | 0.78 | NPC1 (0.49) | TP53LMNAMAPTMEN1KMT2A | |
| SCHEMBL27845679 | 0.77 | THRB (0.47) | TP53LMNAMAPTKMT2AHPGD | |
| SCHEMBL662812 | 0.77 | ALDH1A1 (0.53) | TSHRSMN1; SMN2LMNAKMT2AHPGD | |
| SCHEMBL27633504 | 0.76 | USP2 (0.49) | TSHRNPSR1TP53SMN1; SMN2LMNA | |
| SCHEMBL29725710 | 0.76 | USP2 (0.49) | TSHRNPSR1TP53SMN1; SMN2LMNA | |
| SCHEMBL29868953 | 0.76 | LMNA (0.60) | TSHRTP53SMN1; SMN2LMNAMAPT | |
| SCHEMBL662407 | 0.76 | LMNA (0.60) | TSHRTP53SMN1; SMN2LMNAMAPT | |
| SCHEMBL662880 | 0.75 | MAPT (0.54) | TSHRNPSR1SMN1; SMN2LMNAMAPT | |
| SCHEMBL30361168 | 0.75 | MAPT (0.54) | TSHRNPSR1SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620399-B1 | INDOLONE-ACETAMIDE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA SA (BE) | 2010-09-22 | — | — | EP | claimed |