Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 18/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.71 |
| ▸ | PDE4A | P27815 | 14/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818305 | 0.87 | PDE4D (0.69) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7360312 | 0.86 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6822446 | 0.86 | PDE4D (0.67) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL128167 | 0.84 | PDE4B (0.70) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL142851 | 0.83 | PDE4D (0.54) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1026479 | 0.82 | PDE4D (0.62) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7384113 | 0.81 | PDE4B (0.62) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL7176867 | 0.81 | PDE4B (0.66) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL6817710 | 0.81 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1030765 | 0.81 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4CMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | KOWA COMPANY, LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2172458-A1 | PYRAZOLONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | SERPINE1, SERPINC1, TFPI | PDE4D 1519/4885PDE4B 1700/4885PDE4A 1796/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.