Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.52 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TACR3 | P29371 | 3/20 | 0.51 |
| ▸ | TACR2 | P21452 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376152 | 1.00 | ALDH1A1 (0.63) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL2022347 | 1.00 | ALDH1A1 (0.63) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL15093820 | 0.88 | EPHX2 (0.65) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL186238 | 0.86 | LMNA (0.61) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL186230 | 0.86 | LMNA (0.61) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL186416 | 0.86 | LMNA (0.61) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL3352726 | 0.85 | LMNA (0.53) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL16316844 | 0.85 | LMNA (0.59) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL14535420 | 0.85 | ALDH1A1 (0.59) | ALDH1A1LMNATSHRKDM4EHPGD | |
| SCHEMBL11139016 | 0.85 | LMNA (0.59) | ALDH1A1LMNATSHRKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-7807709-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-10-05 | — | — | US | disclosed |
| US-20080194549-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194549-A1 | Organic Compounds | REN, ACE, OTC | ALDH1A1 224/4885LMNA 3042/4885TSHR 2274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.