Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.57 |
| ▸ | MGAM | O43451 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | SI | P14410 | 5/20 | 0.55 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20913022 | 0.90 | MEN1 (0.54) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL8222200 | 0.86 | MEN1 (0.53) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL1893849 | 0.85 | MEN1 (0.59) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL7047429 | 0.85 | MEN1 (0.59) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL719008 | 0.84 | MAPT (0.57) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL28836352 | 0.84 | GPR84 (0.51) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL6283244 | 0.84 | GPR84 (0.59) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL9162633 | 0.82 | MEN1 (0.56) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL28853261 | 0.82 | MEN1 (0.56) | MEN1KMT2AMAPTPKMGPR84 | |
| SCHEMBL1349263 | 0.82 | MEN1 (0.56) | MEN1KMT2AMAPTPKMGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292557-B | Pyridopyrimidinone mesoion derivative containing indole unit and preparation method and application thereof | 贵州大学 | 2022-02-11 | — | — | CN | disclosed |
| CN-113292557-A | Pyridopyrimidinone mesoion derivative containing indole unit and preparation method and application thereof | 贵州大学 | 2021-08-24 | — | — | CN | disclosed |
| EP-1757585-B1 | Anionically substituted 7-Nitroindoline derivatives and their uses | MEDICAL RES COUNCIL (GB) | 2010-12-01 | — | — | EP | disclosed |
| US-7737169-B2 | Anionically substituted 7-nitroindoline derivatives and their uses | MEDICAL RESEARCH COUNCIL (GB) | 2010-06-15 | — | — | US | disclosed |
| EP-1757585-A1 | Anionically substituted 7-Nitroindoline derivatives and their uses | Medical Research Council (GB) | 2007-02-28 | — | — | EP | disclosed |