Sugi Predict

Sugi Predict / Compounds / SCHEMBL7047429

SCHEMBL7047429

SCHEMBL7047429

O=C(O)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 4/20 0.59
▸ KMT2A Q03164 4/20 0.59
▸ MAPT P10636 3/20 0.59
▸ PKM P14618 1/20 0.59
▸ GPR84 Q9NQS5 4/20 0.56
▸ MGAM O43451 5/20 0.55
▸ GAA P10253 5/20 0.55
▸ SI P14410 5/20 0.55
▸ MGAM2 Q2M2H8 5/20 0.55
▸ FFAR1 O14842 2/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53
▸ KDM4E B2RXH2 2/20 0.51
▸ APAF1 O14727 1/20 0.51
▸ POLB P06746 1/20 0.51
▸ RECQL P46063 1/20 0.51
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ LMNA P02545 1/20 0.51
▸ MPO P05164 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ BLM P54132 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1350711 0.91 MGAM (0.58) MEN1KMT2AMAPTPKMGPR84
SCHEMBL28502723 0.89 MEN1 (0.50) MEN1KMT2AMAPTPKMGPR84
SCHEMBL1893849 0.85 MEN1 (0.59) MEN1KMT2AMAPTPKMGPR84
SCHEMBL3370820 0.85 MEN1 (0.59) MEN1KMT2AMAPTPKMGPR84
SCHEMBL719008 0.84 MAPT (0.57) MEN1KMT2AMAPTPKMGPR84
SCHEMBL6283244 0.84 GPR84 (0.59) MEN1KMT2AMAPTPKMGPR84
SCHEMBL27586464 0.84 ALDH1A1 (0.56) MEN1KMT2AMAPTPKMGPR84
SCHEMBL9162633 0.82 MEN1 (0.56) MEN1KMT2AMAPTPKMGPR84
SCHEMBL30518090 0.82 MEN1 (0.56) MEN1KMT2AMAPTPKMGPR84
SCHEMBL30518932 0.82 MEN1 (0.56) MEN1KMT2AMAPTPKMGPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11337961-B2 Self-emulsifying formulations of DIM-related indoles BIORESPONSE, L.L.C. (US) 2022-05-24 — — US disclosed
CN-109111390-B Met-modified indoloethanol derivative, and synthesis, activity and application thereof 首都医科大学 2021-03-30 — — CN disclosed
US-20210046046-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES BIORESPONSE, L.L.C. 2021-02-18 — — US disclosed
US-10799479-B2 Self-emulsifying formulations of DIM-related indoles BIORESPONSE, L.L.C. (US) 2020-10-13 — — US disclosed
US-10441569-B2 Self-emulsifying formulations of DIM-related indoles BIORESPONSE, L.L.C. (US) 2019-10-15 — — US disclosed
US-20180161308-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES BIORESPONSE, L.L.C. (US) 2018-06-14 — — US disclosed
US-20180161308-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES BIORESPONSE, L.L.C. (US) 2018-06-14 — — US disclosed
US-9918965-B2 Self-emulsifying formulations of DIM-related indoles BIORESPONSE, L.L.C. (US) 2018-03-20 — — US disclosed
US-9918965-B2 Self-emulsifying formulations of DIM-related indoles BIORESPONSE, L.L.C. (US) 2018-03-20 — — US disclosed
US-20170014382-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES BIORESPONSE, L.L.C. (US) 2017-01-19 — — US disclosed
US-20170014382-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES BIORESPONSE, L.L.C. (US) 2017-01-19 — — US disclosed
WO-2014008838-A4 BIS-INDOLYLACETIC ACID DERIVATIVE ATTACHED WITH ARYL SUBSTITUTED METHYL, AND PREPARATION METHOD AND USE THEREOF 永光制药有限公司 (CN) 2014-03-06 — — WO disclosed
WO-2014008838-A1 BIS-INDOLYLACETIC ACID DERIVATIVE ATTACHED WITH ARYL SUBSTITUTED METHYL, AND PREPARATION METHOD AND USE THEREOF 永光制药有限公司 (CN) 2014-01-16 — — WO disclosed
US-6589975-B2 Administering anti-immunogenic and neurogenic inflammatory bis-indole compounds (soritin B, soritin C, soritin D) for treating the condition associated with inflammation THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2003-07-08 — — US disclosed
US-20030022815-A1 Synthetic compounds for treatment of inflammation REGENTS OF THE UNIVERSITY OF CALIFORNIA 2003-01-30 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10441569-B2 Self-emulsifying formulations of DIM-related indoles IDO1, IDO2, CYP8B1 MEN1 2289/4885KMT2A 2446/4885MAPT 1959/4885
US-20210046046-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES IDO1, IDO2, CYP8B1 MEN1 2204/4885KMT2A 1842/4885MAPT 2318/4885
US-11337961-B2 Self-emulsifying formulations of DIM-related indoles IDO1, IDO2, CYP8B1 MEN1 2204/4885KMT2A 1842/4885MAPT 2318/4885
US-20170014382-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES IDO1, IDO2, CYP8B1 MEN1 2289/4885KMT2A 2446/4885MAPT 1959/4885
US-20030022815-A1 Synthetic compounds for treatment of inflammation IDO1, IDO2, CXCL10 MEN1 4345/4885KMT2A 3251/4885MAPT 494/4885
US-10799479-B2 Self-emulsifying formulations of DIM-related indoles IDO1, IDO2, CYP8B1 MEN1 2204/4885KMT2A 1842/4885MAPT 2318/4885
US-20180161308-A1 SELF-EMULSIFYING FORMULATIONS OF DIM-RELATED INDOLES IDO1, IDO2, CYP8B1 MEN1 2289/4885KMT2A 2446/4885MAPT 1959/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.