Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 7/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31391808 | 0.82 | KDM4E (0.62) | PKMKDM4ENAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1881319 | 0.81 | KDM4E (0.60) | PKMKDM4ENAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL21101550 | 0.78 | PKM (0.56) | PKMKDM4ENAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5277365 | 0.78 | PKM (0.56) | PKMKDM4ENAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8682418 | 0.77 | PKM (0.72) | PKMKDM4ENAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL192563 | 0.75 | — | — | |
| SCHEMBL7962955 | 0.75 | — | — | |
| SCHEMBL5725392 | 0.75 | — | — | |
| SCHEMBL255470 | 0.74 | PKM (0.62) | PKMKDM4ENAMPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1964733 | 0.74 | NAMPT (0.72) | PKMKDM4ENAMPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029572-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| EP-2029572-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007143597-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-12-13 | — | — | WO | disclosed |