Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11243776 | 0.91 | CYP1B1 (0.42) | ALDH1A1HSD17B10TSHRHPGDCYP3A4 | |
| SCHEMBL248440 | 0.79 | SLC6A4 (0.59) | ALDH1A1HSD17B10TSHRHPGDCYP3A4 | |
| SCHEMBL30477104 | 0.79 | SLC6A4 (0.59) | ALDH1A1HSD17B10TSHRHPGDCYP3A4 | |
| SCHEMBL18989480 | 0.75 | HTR2C (0.38) | ACHEBCHE | |
| SCHEMBL2747075 | 0.73 | KDM4E (0.42) | ALDH1A1HSD17B10HPGDKDM1AKDM4E | |
| SCHEMBL29127161 | 0.72 | ALDH1A1 (0.45) | ALDH1A1HSD17B10TSHRHPGDCYP3A4 | |
| SCHEMBL29222020 | 0.72 | DRD2 (0.39) | ALDH1A1HSD17B10TSHRHPGDKDM1A | |
| SCHEMBL15413698 | 0.72 | ALDH1A1 (0.44) | ALDH1A1HSD17B10TSHRHPGDKDM1A | |
| SCHEMBL28545139 | 0.72 | ALDH1A1 (0.52) | ALDH1A1HSD17B10TSHRHPGDKDM1A | |
| SCHEMBL3968194 | 0.71 | SLC6A4 (0.56) | ALDH1A1HSD17B10TSHRHPGDKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048592-A1 | COMPOSITIONS COMPRISING 4- (2- ( 5-BR0M0-4- ( 1-CYCLOPROPYLNAPHTHALEN-4-YL) -4H-1, 2, 4-TRIAZ0L-3-YLTHI0) ACETAMIDO -3-CHLOROBENZOIC ACID AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | ARDEA BIOSCIENCES, INC. (US) | 2010-04-29 | — | — | WO | disclosed |