Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39276 | 0.82 | TDP1 (0.57) | ATMTDP1ELANEALDH1A1KMT2A | |
| SCHEMBL25220465 | 0.79 | KMT2A (0.53) | ATMTDP1BCAT2HCAR2ALDH1A1 | |
| SCHEMBL8797288 | 0.75 | ELANE (0.53) | ATMTDP1ELANEALDH1A1KMT2A | |
| SCHEMBL28064884 | 0.75 | CES2 (0.58) | ATMTDP1ELANEALDH1A1GAA | |
| Styrene SCHEMBL28090716 | 0.72 | ATM (0.48) | ATMTDP1ELANEALDH1A1KMT2A | |
| SCHEMBL9124237 | 0.72 | TDP1 (0.53) | ATMTDP1ELANEALDH1A1HTT | |
| SCHEMBL506074 | 0.72 | TDP1 (0.53) | ATMTDP1ELANEALDH1A1HTT | |
| SCHEMBL27769200 | 0.72 | ALDH1A1 (0.55) | ATMHCAR2ALDH1A1KMT2AMEN1 | |
| SCHEMBL6454355 | 0.70 | ALDH1A1 (0.64) | ATMTDP1BCAT2HCAR2ALDH1A1 | |
| SCHEMBL5132603 | 0.70 | TDP1 (0.56) | ATMTDP1ELANEALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |