Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.59 |
| ▸ | PDE4A | P27815 | 3/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375192 | 0.84 | MAPT (0.69) | KDM4EMAPTTHRBPDE4BPDE4A | |
| SCHEMBL3371490 | 0.82 | PDE4B (0.56) | KDM4EMAPTTHRBPDE4BPDE4A | |
| SCHEMBL3373532 | 0.79 | MAPT (0.69) | KDM4EMAPTTHRBPDE4BPDE4A | |
| SCHEMBL7361110 | 0.78 | PDE4B (0.56) | KDM4EPDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3773831 | 0.78 | PDE4B (0.55) | KDM4EMAPTPDE4BPDE4APDE4C | |
| SCHEMBL7355624 | 0.77 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4DNPY5R | |
| SCHEMBL3374189 | 0.75 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DNPY5R | |
| SCHEMBL7359838 | 0.74 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DSLC6A4 | |
| SCHEMBL3374398 | 0.74 | PDE4B (0.57) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3374951 | 0.72 | KDM4E (0.68) | KDM4EMAPTTHRBPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | KOWA COMPANY, LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2172458-A1 | PYRAZOLONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | SERPINE1, SERPINC1, TFPI | KDM4E 4172/4885MAPT 2810/4885THRB 2909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.