Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 10/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911720 | 0.90 | CHRM3 (0.33) | CHRM3ATMPDE4DEGFRGABRA2 | |
| SCHEMBL7931506 | 0.83 | PDE4D (0.36) | CHRM3ATMPDE4DTHRB | |
| SCHEMBL3378468 | 0.83 | PDE4D (0.38) | CHRM3ATMPDE4DEGFRGABRA2 | |
| SCHEMBL3379763 | 0.76 | TRPM8 (0.39) | CHRM3PDE4DEGFRGABRA2GABRB2 | |
| SCHEMBL3381843 | 0.75 | GPR119 (0.39) | CHRM3PDE4DEGFRKMT2AHPGD | |
| SCHEMBL7913069 | 0.73 | HDAC6 (0.44) | CHRM3PDE4DEGFR | |
| SCHEMBL10442054 | 0.66 | PDE4D (0.47) | PDE4DEGFRTHRBNPC1ALDH1A1 | |
| SCHEMBL7921942 | 0.66 | CHRM3 (0.31) | CHRM3KMT2AALDH1A1 | |
| SCHEMBL7916793 | 0.66 | DPP4 (0.39) | KMT2ATHRBALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3466382 | 0.66 | PDE4D (0.62) | PDE4DALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |