Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377149 | 0.89 | HDAC6 (0.43) | HDAC6EPHB4JAK2GPR119RET | |
| SCHEMBL3379763 | 0.84 | TRPM8 (0.39) | GPR119PDE4DCHRM3EGFR | |
| SCHEMBL3381843 | 0.81 | GPR119 (0.39) | JAK2GPR119PDE4DCHRM3EGFR | |
| SCHEMBL3380305 | 0.80 | HDAC6 (0.44) | HDAC6EPHB4JAK2RETNAMPT | |
| SCHEMBL3379666 | 0.80 | MAPK14 (0.48) | HDAC6EPHB4JAK2CYP3A4 | |
| SCHEMBL3378468 | 0.79 | PDE4D (0.38) | GPR119PDE4DCHRM3EGFR | |
| SCHEMBL10442054 | 0.74 | PDE4D (0.47) | PDE4DEGFR | |
| SCHEMBL3466382 | 0.74 | PDE4D (0.62) | PDE4DFFAR1 | |
| SCHEMBL3377436 | 0.73 | HDAC6 (0.39) | HDAC6EPHB4RETPDE4DNAMPT | |
| SCHEMBL3375932 | 0.73 | CHRM3 (0.35) | PDE4DCHRM3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |