Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13337352 | 0.78 | S1PR1 (0.36) | MTNR1ABRD4S1PR1S1PR3PDGFRB | |
| SCHEMBL6687227 | 0.78 | MAPK1 (0.41) | — | |
| SCHEMBL15451257 | 0.76 | KMT2A (0.49) | — | |
| SCHEMBL15451247 | 0.75 | PPARA (0.41) | MTNR1A | |
| SCHEMBL15451286 | 0.75 | PPARA (0.41) | MTNR1A | |
| SCHEMBL6687224 | 0.75 | CRBN (0.34) | PRMT5WDR77HTR1AMTNR1ABRD4 | |
| SCHEMBL3376891 | 0.75 | ADRB2 (0.34) | ADRA2AADRA2BADRA2CHTR1AADRB2 | |
| SCHEMBL20373858 | 0.74 | NISCH (0.42) | ADRA2AADRA2BADRA2CS1PR1S1PR3 | |
| SCHEMBL13003057 | 0.74 | ADRA2A (0.33) | ADRA2AADRA2BADRA2C | |
| SCHEMBL3304107 | 0.72 | LMNA (0.44) | PRMT5WDR77BRD4S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757585-B1 | Anionically substituted 7-Nitroindoline derivatives and their uses | MEDICAL RES COUNCIL (GB) | 2010-12-01 | — | — | EP | disclosed |
| US-7737169-B2 | Anionically substituted 7-nitroindoline derivatives and their uses | MEDICAL RESEARCH COUNCIL (GB) | 2010-06-15 | — | — | US | disclosed |
| EP-1757585-A1 | Anionically substituted 7-Nitroindoline derivatives and their uses | Medical Research Council (GB) | 2007-02-28 | — | — | EP | disclosed |