Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.67 |
| ▸ | PDE4A | P27815 | 13/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765559 | 0.90 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7501628 | 0.83 | PDE4A (0.97) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7444846 | 0.81 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3373719 | 0.80 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3770826 | 0.80 | PDE4A (0.54) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL3773831 | 0.78 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL3370231 | 0.78 | PDE4A (0.52) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL30009845 | 0.76 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL1028427 | 0.76 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL28265414 | 0.76 | MAPT (0.51) | KDM4EALDH1A1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | KOWA COMPANY, LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2172458-A1 | PYRAZOLONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | SERPINE1, SERPINC1, TFPI | PDE4B 1700/4885PDE4A 1796/4885PDE4C 2308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.