SCHEMBL3376852

CC(C)CNC(=O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1.CC(O)CNC(=O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1.CCC(CO)NC(=O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1.CCNC(=O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1.COCCNC(=O)c1cccc(N(Cc2ccccc2)S(=O)(=O)c2ccccc2)c1

nearest known ligand 0.42

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	MAPT	P10636	6/20	0.42

▸	LMNA	P02545	5/20	0.42

▸	CNR2	P34972	1/20	0.39

▸	ALDH1A1	P00352	2/20	0.39

▸	HPGD	P15428	1/20	0.38

▸	KDM4E	B2RXH2	2/20	0.38

▸	KMT2A	Q03164	1/20	0.37

▸	SMN1; SMN2	Q16637	2/20	0.37

▸	NPC1	O15118	1/20	0.37

▸	TP53	P04637	1/20	0.37

▸	RAB9A	P51151	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3379243	0.83	MAPT (0.55)	MAPTLMNAALDH1A1KDM4EKMT2A
SCHEMBL3378124	0.83	MAPT (0.55)	MAPTLMNAALDH1A1KDM4EKMT2A
SCHEMBL3378933	0.81	MAPT (0.59)	MAPTLMNAALDH1A1KDM4EKMT2A
SCHEMBL3379295	0.81	MAPT (0.57)	MAPTLMNACNR2ALDH1A1KDM4E
SCHEMBL3379886	0.80	LMNA (0.59)	MAPTLMNACNR2ALDH1A1KDM4E
SCHEMBL303248	0.78	LMNA (0.59)	MAPTLMNAALDH1A1KDM4EKMT2A
SCHEMBL3376241	0.78	LMNA (0.61)	MAPTLMNAALDH1A1KDM4EKMT2A
SCHEMBL3379037	0.76	MAPT (0.57)	MAPTLMNAALDH1A1KDM4EKMT2A
SCHEMBL2185822	0.76	RAB9A (0.59)	MAPTLMNAALDH1A1KDM4EKMT2A
SCHEMBL303249	0.75	LMNA (0.56)	MAPTLMNAALDH1A1KDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2010023448-A1	NOVEL POTASSIUM CHANNEL BLOCKERS	XENTION LIMITED (GB)	2010-03-04	—	—	WO	claimed