Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507009 | 1.00 | IRAK4 (0.47) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL8508451 | 1.00 | IRAK4 (0.47) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL1002816 | 0.87 | HTT (0.50) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL17374631 | 0.85 | IRAK4 (0.47) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL28845213 | 0.85 | KDM4E (0.47) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL5575146 | 0.85 | TSHR (0.40) | ALDH1A1MAPTTSHRHPGDKMT2A | |
| SCHEMBL29136235 | 0.84 | IRAK4 (0.40) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL5935461 | 0.84 | IRAK4 (0.40) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL30776574 | 0.84 | IRAK4 (0.40) | IRAK4HTTALDH1A1MAPTTSHR | |
| SCHEMBL19143527 | 0.82 | KDM4E (0.49) | IRAK4HTTALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117776953-A | Preparation method of N, N-di (beta-hydroxypropyl) benzamide | 南京红宝丽醇胺化学有限公司 | 2024-03-29 | — | — | CN | claimed |
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | claimed |
| EP-4377318-A1 | PYRROLO [2, 3-B] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BeiGene, Ltd. (KY) | 2024-06-05 | — | — | EP | disclosed |
| US-11964953-B2 | Substituted aminothiazoles as DGKzeta inhibitors for immune activation | BAYER AKTIENGESELLSCHAFT (DE) | 2024-04-23 | — | — | US | disclosed |
| CN-117801589-A | Matting agent for powder coating and application thereof, matting powder coating and application thereof | 安徽省华安进出口有限公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-117776953-A | Preparation method of N, N-di (beta-hydroxypropyl) benzamide | 南京红宝丽醇胺化学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117776953-A | Preparation method of N, N-di (beta-hydroxypropyl) benzamide | 南京红宝丽醇胺化学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117776953-A | Preparation method of N, N-di (beta-hydroxypropyl) benzamide | 南京红宝丽醇胺化学有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-116410105-A | Preparation method of difunctional alkylbenzene hydroxyalkylamide | 南京红宝丽醇胺化学有限公司 | 2023-07-11 | — | — | CN | disclosed |
| CN-115093732-B | Low-functionality curing agent blend and high-gloss powder coating | 安徽省华安进出口有限公司 | 2023-05-23 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |
| US-9447033-B2 | Potassium channel blockers | JAPAN TOBACCO INC. (JP) | 2016-09-20 | — | — | US | disclosed |
| US-20150259282-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2015-09-17 | — | — | US | disclosed |
| US-9073834-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2015-07-07 | — | — | US | disclosed |
| US-20140221337-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2014-08-07 | — | — | US | disclosed |
| US-8673901-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2014-03-18 | — | — | US | disclosed |
| US-20100087428-A1 | Novel Potassium Channel Blockers | XENTION LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221337-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | IRAK4 2907/4885HTT 2305/4885ALDH1A1 1360/4885 |
| US-20100087428-A1 | Novel Potassium Channel Blockers | HCN4, SCN2B, KCNH2 | IRAK4 2942/4885HTT 2035/4885ALDH1A1 3795/4885 |
| US-11964953-B2 | Substituted aminothiazoles as DGKzeta inhibitors for immune activation | DGKZ, DGKA, DGKG | IRAK4 381/4885HTT 3914/4885ALDH1A1 3985/4885 |
| US-20150259282-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | IRAK4 2907/4885HTT 2305/4885ALDH1A1 1360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.