Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.59 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459829 | 0.85 | TBXA2R (0.60) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL19687545 | 0.84 | TBXA2R (0.66) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL9761425 | 0.83 | TBXA2R (0.59) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL7308054 | 0.77 | TBXA2R (0.51) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL9759993 | 0.77 | CYP2C9 (0.52) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL30516334 | 0.77 | TBXA2R (0.56) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL3181833 | 0.77 | NR1I2 (0.51) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL25377373 | 0.76 | TBXA2R (0.90) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| SCHEMBL28342101 | 0.76 | TBXA2R (0.60) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 | |
| Amlodipine SCHEMBL1560959 | 0.76 | CYP3A4 (1.00) | CYP3A4NR1I2TBXA2RADRA1ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117945986-A | Crystal form of maleic acid levamlodipine and preparation method and application thereof | 常州瑞明药业有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-114478571-B | Preparation method of amlodipine besylate degradation impurities and detection method of impurities in amlodipine besylate | 安徽美致诚药业有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-116332832-A | Maleic acid levo-amlodipine amorphous crystal form and preparation method thereof | 安徽美致诚药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-115974769-A | Levamlodipine maleate crystal form, and preparation method and application thereof | 常州瑞明药业有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115850159-A | Preparation method of levamlodipine maleate | 常州瑞明药业有限公司 | 2023-03-28 | — | — | CN | disclosed |
| CN-114478571-A | Preparation method of amlodipine besylate degradation impurities and detection method of impurities in amlodipine besylate | 安徽美致诚药业有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-9314454-B2 | Oral cavity disintegrating tablet and method of producing the same | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 2016-04-19 | — | — | US | disclosed |
| EP-2233129-B1 | ORAL CAVITY DISINTEGRATING TABLET AND METHOD OF PRODUCING THE SAME | SAWAI SEIYAKU KK (JP) | 2014-05-07 | — | — | EP | disclosed |
| US-20100278930-A1 | ORAL CAVITY DISINTEGRATING TABLET AND METHOD OF PRODUCING THE SAME | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 2010-11-04 | — | — | US | disclosed |
| EP-2233129-A1 | ORAL CAVITY DISINTEGRATING TABLET AND METHOD OF PRODUCING THE SAME | Sawai Pharmaceutical Co., Ltd. (JP) | 2010-09-29 | — | — | EP | disclosed |
| EP-0993447-B1 | A PROCESS FOR THE PREPARATION OF AMLODIPINE BENZENESULPHONATE | ADAMED SP ZOO (PL) | 2005-08-17 | — | — | EP | disclosed |
| US-5391548-A | Transdermal flux enhancing compositions to treat hypertension, diabetes and angina pectoris | PFIZER INC. (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0271983-B1 | TRANSDERMAL FLUX ENHANCING COMPOSITIONS | PFIZER INC. (US) | 1991-06-12 | — | — | EP | disclosed |