Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.60 |
| ▸ | DRD1 | P21728 | 2/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.60 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9761425 | 0.98 | TBXA2R (0.59) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL7308054 | 0.92 | TBXA2R (0.51) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL9759993 | 0.92 | CYP2C9 (0.52) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL9760727 | 0.88 | ADRA1A (0.47) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL9760672 | 0.87 | CYP2C9 (0.50) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL9760259 | 0.87 | HTR1A (0.46) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL9760234 | 0.86 | TBXA2R (0.47) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL9760040 | 0.86 | HTR1A (0.46) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL19687545 | 0.86 | TBXA2R (0.66) | TBXA2RADRA1ASLC6A3ABCB11HTR1A | |
| SCHEMBL9760769 | 0.85 | TBXA2R (0.43) | TBXA2RADRA1ASLC6A3ABCB11HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004783-A1 | Crystalline forms of amlodipine maleate | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-04 | — | — | US | disclosed |
| US-20040072879-A1 | Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine) | DR. REDDY'S LABORATORIES LIMITED | 2004-04-15 | — | — | US | disclosed |
| US-20040072879-A1 | Crystalline 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine maleate salt (Amlodipine) | DR. REDDY'S LABORATORIES LIMITED | 2004-04-15 | — | — | US | disclosed |
| US-4670449-A | HYPOTENSIVE AGENTS | PFIZER INC. (US) | 1987-06-02 | — | — | US | disclosed |
| US-4661485-A | 2-pyrimidylaminoalkoxymethyl-6-methyl-3,5-bis (alkoxycarbony-1)-1,4-dihydropyridine antihypertensive agents | PFIZER INC. (US) | 1987-04-28 | — | — | US | disclosed |
| US-4572909-A | 2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents | PFIZER INC. (US) | 1986-02-25 | — | — | US | disclosed |
| US-4572908-A | HYPOTENSIVE AND ANTIISCHEMIC AGENTS | PFIZER INC. (US) | 1986-02-25 | — | — | US | disclosed |
| EP-0116769-A1 | Dihydropyridines | Pfizer Limited (GB) | 1984-08-29 | — | — | EP | disclosed |
| EP-0089167-A2 | Dihydropyridine anti-ischaemic and antihypertensive agents, processes for their production, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1983-09-21 | — | — | EP | disclosed |