Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CUL4A | Q13619 | 2/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28949857 | 0.82 | KDM4E (0.39) | MAPTRAB9APOLBALDH1A1KMT2A | |
| SCHEMBL27739264 | 0.77 | TSHR (0.45) | MAPTNPC1RAB9APKMPOLB | |
| SCHEMBL8516383 | 0.69 | TSHR (0.52) | ALOX5MAPTPOLBALDH1A1KMT2A | |
| SCHEMBL19020580 | 0.69 | PDE10A (0.36) | — | |
| SCHEMBL3842038 | 0.68 | GABRA1 (0.39) | MAPTALDH1A1KMT2AMEN1CYP1A2 | |
| SCHEMBL29480246 | 0.68 | MEN1 (0.41) | POLBALDH1A1KMT2AMEN1CA2 | |
| SCHEMBL7456124 | 0.66 | ALDH1A1 (0.51) | MAPTNPC1RAB9APKMNPSR1 | |
| SCHEMBL1958548 | 0.66 | TYMS (0.49) | ALOX5MAPTNPC1RAB9APOLB | |
| SCHEMBL11727074 | 0.66 | CYP2A6 (0.42) | CYP2C9CYP2C19CYP3A4ICAM1SELE | |
| SCHEMBL7785899 | 0.66 | ALDH1A1 (0.38) | ALOX5ALDH1A1KMT2ACA2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038288-B1 | NOVEL 4-AMINO-3-(-AZOLYL-PHENOXYMETHYL)-THIENOÝ3,2¨PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | claimed |