Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376754 | 0.94 | CHRM5 (0.61) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL18898618 | 0.84 | NCF1 (0.41) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL25001356 | 0.81 | SIGMAR1 (0.41) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL19612775 | 0.76 | CHRM5 (0.84) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL1241238 | 0.76 | CHRM5 (0.84) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL4824721 | 0.76 | CHRM5 (0.84) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL3632436 | 0.76 | CHRM5 (0.84) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL24940877 | 0.75 | CHRM5 (0.39) | CHRM5ADRA2CSCN1ASCN4ASCN7A | |
| SCHEMBL24475309 | 0.75 | ACHE (0.42) | CHRM5ADRA2CACHEOPRL1OPRM1 | |
| SCHEMBL14996488 | 0.75 | NCF1 (0.43) | CHRM5ADRA2CSCN1ASCN4ASCN7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557836-B2 | Spiro-piperidine inhibitors | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-10-15 | — | — | US | disclosed |
| US-20100069420-A1 | SPIRO-PIPERIDINE INHIBITORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069420-A1 | SPIRO-PIPERIDINE INHIBITORS | HSP90B1, PSTPIP2, HAVCR2 | CHRM5 1926/4885ADRA2C 290/4885SCN1A 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.