Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9696696 | 0.93 | ADRA2A (0.86) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8543848 | 0.92 | ADRA2A (0.85) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8540633 | 0.90 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9698298 | 0.90 | ADRA2A (0.81) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9696706 | 0.90 | ADRA2A (0.80) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8542507 | 0.90 | ADRA2A (0.80) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL14761542 | 0.89 | ADRA2A (0.80) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8537885 | 0.89 | ADRA2A (0.80) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL17242001 | 0.89 | ADRA2A (0.79) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL29515688 | 0.89 | HTR1A (0.82) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5106850-A | INDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-21 | — | — | US | claimed |
| JP-3052859-A | — | — | None | — | — | JP | disclosed |
| WO-2012002583-A1 | METHOD FOR TREATING SCHIZOPHRENIA AND RELATED DISEASES WITH A COMBINATION THERAPY | VANDERBILT UNIVERSITY (US) | 2012-01-05 | — | — | WO | disclosed |
| US-20040023948-A1 | Fast-dispersing dosage form containing 5-HT1 agonists | CATALENT USA PAINTBALL, INC. | 2004-02-05 | — | — | US | disclosed |
| EP-0969842-A1 | PHARMACEUTICAL COMPOSITION | R.P. Scherer Limited (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998042344-A1 | PHARMACEUTICAL COMPOSITION | R. P. SCHERER LIMITED (GB) | 1998-10-01 | — | — | WO | disclosed |
| US-5106850-A | INDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-21 | — | — | US | disclosed |
| JP-H0352859-A | INDOLE DERIVATIVE | MERCK PATENT GMBH | 1991-03-07 | — | — | JP | disclosed |