Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378561 | 0.85 | FPR2 (0.49) | HRH3FPR2PROKR1 | |
| SCHEMBL3376186 | 0.84 | TSHR (0.36) | SMN1; SMN2TSHRTP53ALDH1A1NPSR1 | |
| SCHEMBL3377923 | 0.83 | HRH3 (0.43) | HRH3ALDH1A1POLB | |
| SCHEMBL3375325 | 0.83 | HRH3 (0.43) | HRH3ALDH1A1KMT2AGAAPOLB | |
| SCHEMBL3377335 | 0.82 | HRH3 (0.48) | HRH3ALDH1A1POLB | |
| SCHEMBL3378015 | 0.82 | HRH3 (0.45) | HRH3TP53ALDH1A1POLB | |
| SCHEMBL3378079 | 0.81 | HRH3 (0.48) | HRH3ALDH1A1POLB | |
| SCHEMBL3380045 | 0.81 | HRH3 (0.44) | HRH3ALDH1A1NPSR1POLB | |
| SCHEMBL3376046 | 0.81 | HRH3 (0.44) | HRH3SMN1; SMN2TSHRALDH1A1LMNA | |
| SCHEMBL3378149 | 0.81 | HRH3 (0.42) | HRH3SMN1; SMN2ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |