Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381234 | 0.87 | FPR2 (0.39) | ALDH1A1BCL2BCL2L1MEN1KMT2A | |
| SCHEMBL3380067 | 0.86 | FPR2 (0.39) | LMNAALDH1A1NPSR1 | |
| SCHEMBL3377307 | 0.85 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL3379142 | 0.84 | HRH3 (0.41) | TSHRLMNAALDH1A1NPSR1MAPT | |
| SCHEMBL3376674 | 0.84 | CXCR4 (0.41) | LMNAALDH1A1KMT2ATP53KDM4E | |
| SCHEMBL3380056 | 0.83 | CXCR4 (0.45) | TSHRALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL3376045 | 0.83 | KDM4E (0.41) | TSHRALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3379302 | 0.83 | CXCR4 (0.42) | ALDH1A1NPSR1SMN1; SMN2KDM4EPOLB | |
| SCHEMBL3378684 | 0.82 | ALDH1A1 (0.36) | LMNAALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL3378045 | 0.82 | KDM4E (0.40) | ALDH1A1MEN1KMT2ATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |