Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 5/20 | 0.33 |
| ▸ | BCHE | P06276 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379341 | 1.00 | HRH3 (0.38) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3380494 | 0.82 | RORC (0.38) | KDM4EALDH1A1ACHEBCHEMAOB | |
| SCHEMBL3380491 | 0.82 | RORC (0.38) | KDM4EALDH1A1ACHEBCHEMAOB | |
| SCHEMBL3376555 | 0.82 | HRH3 (0.38) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3376557 | 0.82 | HRH3 (0.38) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3442154 | 0.80 | HRH3 (0.36) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3377216 | 0.80 | HRH3 (0.39) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3442149 | 0.78 | HRH3 (0.52) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3442151 | 0.78 | HRH3 (0.52) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3379717 | 0.78 | KDM4E (0.37) | HRH3CHEK1RPS6KB1FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | disclosed |
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | disclosed |