Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377214 | 0.87 | NCF1 (0.37) | CXCR4ALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL3377217 | 0.87 | NCF1 (0.37) | CXCR4ALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL3381143 | 0.86 | KDM4E (0.46) | CXCR4ALDH1A1KDM4EPOLBCYP2A13 | |
| SCHEMBL3378843 | 0.86 | KDM4E (0.46) | CXCR4ALDH1A1KDM4EPOLBCYP2A13 | |
| SCHEMBL3375004 | 0.79 | ALDH1A1 (0.39) | CXCR4ALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL3377162 | 0.79 | ALDH1A1 (0.39) | CXCR4ALDH1A1KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL3377530 | 0.78 | KDM4E (0.46) | CXCR4ALDH1A1KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL3376557 | 0.78 | HRH3 (0.38) | CXCR4ALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL3376555 | 0.78 | HRH3 (0.38) | CXCR4ALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL3376436 | 0.77 | HPGD (0.42) | ALDH1A1KDM4EPOLBSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | disclosed |