Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 7/20 | 0.38 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CDK11B | P21127 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14929435 | 0.83 | SYK (0.56) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14911001 | 0.74 | SYK (0.56) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14909820 | 0.72 | SYK (0.65) | SYKZAP70CAMK1DKCNH2AURKB | |
| SCHEMBL14923850 | 0.67 | SYK (0.71) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14929769 | 0.66 | SYK (0.56) | SYKZAP70KCNH2AURKB | |
| SCHEMBL17018670 | 0.64 | SYK (0.51) | SYKZAP70CDK1KCNH2AURKB | |
| SCHEMBL14923870 | 0.64 | SYK (0.69) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL14923793 | 0.64 | SYK (0.65) | SYKZAP70CAMK1DPRKCEBTK | |
| SCHEMBL16559049 | 0.63 | DHFR (0.38) | SYKZAP70CAMK1DCDK1PRKCA | |
| SCHEMBL13996789 | 0.62 | TRPA1 (0.51) | TAS2R14RAPGEF4NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012002577-A1 | NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF | 富士フイルム株式会社 (JP) | 2012-01-05 | — | — | WO | disclosed |