Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 17/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379579 | 0.89 | KDR (0.43) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3382693 | 0.87 | WNT3A (0.41) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL3385390 | 0.84 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3385528 | 0.84 | FGFR3 (0.46) | KDRFGFR3MEN1RAB9AKMT2A | |
| SCHEMBL3383557 | 0.83 | KDR (0.44) | KDRFGFR3 | |
| SCHEMBL3380785 | 0.82 | FGFR3 (0.36) | KDRFGFR3SMN1; SMN2 | |
| SCHEMBL4973341 | 0.82 | FGFR3 (0.42) | KDRFGFR3MEN1RAB9AKMT2A | |
| SCHEMBL3187730 | 0.81 | KDR (0.41) | KDRFGFR3MEN1RAB9AKMT2A | |
| SCHEMBL3381798 | 0.81 | KDR (0.48) | KDRFGFR3 | |
| SCHEMBL3383608 | 0.80 | SMN1; SMN2 (0.34) | KDRFGFR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |