Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | APAF1 | O14727 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380277 | 1.00 | SMN1; SMN2 (0.65) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL3382468 | 0.89 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL3382466 | 0.89 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL29233344 | 0.88 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL828692 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL828693 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL29773596 | 0.87 | KDM4E (0.61) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL29773608 | 0.87 | KDM4E (0.61) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL22383972 | 0.86 | KDM4E (0.68) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL3855611 | 0.86 | KDM4E (0.68) | SMN1; SMN2KDM4EMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120555-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | Heller, Adam (US) | 2009-11-25 | — | — | EP | claimed |
| US-20080287866-A1 | Methods and compositions for the treatment of pain | HELLER ADAM | 2008-11-20 | — | — | US | claimed |
| WO-2008094664-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | HELLER ADAM (US) | 2008-08-07 | — | — | WO | claimed |
| US-20220403428-A1 | YEAST CELLS AND METHODS FOR PRODUCTION OF TRYPTOPHAN DERIVATIVES | DANMARKS TEKNISKE UNIVERSITET (DK) | 2022-12-22 | — | — | US | disclosed |
| WO-2010017405-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | HELLER ADAM (US) | 2010-02-11 | — | — | WO | disclosed |
| EP-2120555-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | Heller, Adam (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080287866-A1 | Methods and compositions for the treatment of pain | HELLER ADAM | 2008-11-20 | — | — | US | disclosed |
| WO-2008094664-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | HELLER ADAM (US) | 2008-08-07 | — | — | WO | disclosed |
| US-4015008-A | N,N-dichloro substituted aminocarboxylic acids as microbiocides | NATIONAL PATENT DEVELOPMENT CORPORATION (US) | 1977-03-29 | — | — | US | disclosed |
| US-3950536-A | N,N-Dichloro substituted aminocarboxylic acids as bactericides and fungicides | BARER SOL JOSEPH | 1976-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287866-A1 | Methods and compositions for the treatment of pain | ACHE, S100P, P2RX3 | SMN1; SMN2 887/4885KDM4E 3401/4885MAPT 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.