SCHEMBL828693

SCHEMBL828693

O=C(O)[C@H](Cc1c[nH]c2ccccc12)N(O)O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.67
KDM4E B2RXH2 3/20 0.65
MAPT P10636 3/20 0.65
KMT2A Q03164 3/20 0.65
MEN1 O00255 2/20 0.65
POLB P06746 2/20 0.65
APAF1 O14727 1/20 0.65
RECQL P46063 1/20 0.65
L3MBTL1 Q9Y468 1/20 0.65
LMNA P02545 1/20 0.65
MPO P05164 1/20 0.65
TSHR P16473 1/20 0.65
BLM P54132 1/20 0.65
PMP22 Q01453 1/20 0.65
HIF1A Q16665 1/20 0.65
DNMT1 P26358 3/20 0.56
CYP2C19 P33261 1/20 0.55
DNMT3B Q9UBC3 1/20 0.55
PKM P14618 1/20 0.55
ALOX15 P16050 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL828692 1.00 SMN1; SMN2 (0.67) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL31414630 0.89 SMN1; SMN2 (0.63) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL1162356 0.87 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL6843791 0.87 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL6843792 0.87 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL3855611 0.87 KDM4E (0.68) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL3380280 0.87 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL3380277 0.87 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL1162357 0.87 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AMEN1
SCHEMBL3378235 0.87 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EMAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 132 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110201947-A1 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2011-08-18 US claimed
EP-2268305-A2 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE The Cleveland Clinic Foundation (US) 2011-01-05 EP claimed
WO-2009114875-A2 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2009-09-17 WO claimed
US-20250289868-A1 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME REGENERON PHARMA (US) 2025-09-18 US disclosed
US-12338274-B2 Anti-VEGF protein compositions and methods for producing the same REGENERON PHARMACEUTICALS, INC. (US) 2025-06-24 US disclosed
US-20250197474-A1 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME REGENERON PHARMACEUTICALS, INC. 2025-06-19 US disclosed
US-12319728-B2 Anti-VEGF protein compositions and methods for producing the same REGENERON PHARMACEUTICALS, INC. (US) 2025-06-03 US disclosed
EP-4524236-A2 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME Regeneron Pharmaceuticals, Inc. (US) 2025-03-19 EP disclosed
EP-4524148-A2 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME Regeneron Pharmaceuticals, Inc. (US) 2025-03-19 EP disclosed
EP-4524237-A2 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME Regeneron Pharmaceuticals, Inc. (US) 2025-03-19 EP disclosed
EP-4524147-A2 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME Regeneron Pharmaceuticals, Inc. (US) 2025-03-19 EP disclosed
EP-2510361-A2 DETECTION OF OXIDIZED POLYPEPTIDES Purdue Research Foundation (US) 2012-10-17 EP disclosed
US-8143224-B2 Oxidant resistant apolipoprotein A-1 and mimetic peptides THE CLEVELAND CLINIC FOUNDATION (US) 2012-03-27 US disclosed
US-20110201947-A1 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2011-08-18 US disclosed
WO-2011072197-A2 DETECTION OF OXIDIZED POLYPEPTIDES PURDUE RESEARCH FOUNDATION (US) 2011-06-16 WO disclosed
EP-2268305-A2 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE The Cleveland Clinic Foundation (US) 2011-01-05 EP disclosed
EP-2212351-A1 OXIDANT RESISTANT APOLIPOPROTEIN A-1 AND MIMETIC PEPTIDES The Cleveland Clinic Foundation (US) 2010-08-04 EP disclosed
WO-2009114875-A2 OXIDIZED PARAOXONASE 1 AND PARAOXONASE 1/HDL PARTICLE NUMBER RATIO AS RISK MARKERS FOR CARDIOVASCULAR DISEASE THE CLEVELAND CLINIC FOUNDATION (US) 2009-09-17 WO disclosed
US-20090149390-A1 OXIDANT RESISTANT APOLIPOPROTEIN A-1 AND MIMETIC PEPTIDES THE CLEVELAND CLINIC FOUNDATION 2009-06-11 US disclosed
WO-2009055538-A1 OXIDANT RESISTANT APOLIPOPROTEIN A-1 AND MIMETIC PEPTIDES THE CLEVELAND CLINIC FOUNDATION (US) 2009-04-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12338274-B2 Anti-VEGF protein compositions and methods for producing the same VEGFA, HDGF, PDGFA SMN1; SMN2 3864/4885KDM4E 3284/4885MAPT 2868/4885
US-20250197474-A1 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME VEGFA, HDGF, PDGFA SMN1; SMN2 3864/4885KDM4E 3284/4885MAPT 2868/4885
US-12319728-B2 Anti-VEGF protein compositions and methods for producing the same VEGFA, HDGF, PDGFA SMN1; SMN2 3864/4885KDM4E 3284/4885MAPT 2868/4885
US-20250289868-A1 ANTI-VEGF PROTEIN COMPOSITIONS AND METHODS FOR PRODUCING THE SAME VEGFA, HDGF, PDGFA SMN1; SMN2 3864/4885KDM4E 3284/4885MAPT 2868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.