Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 7/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKLR | P30613 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376046 | 0.86 | HRH3 (0.44) | HRH3ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL3377343 | 0.86 | SOS1 (0.44) | HRH3ALDH1A1KDM4E | |
| SCHEMBL3378015 | 0.85 | HRH3 (0.45) | HRH3ALDH1A1KDM4E | |
| SCHEMBL3380356 | 0.85 | HRH3 (0.42) | HRH3ALDH1A1LMNAL3MBTL1TSHR | |
| SCHEMBL3377315 | 0.85 | ALDH1A1 (0.41) | ALDH1A1HTTHPGDPKMKDM4E | |
| SCHEMBL3376233 | 0.84 | HRH3 (0.42) | HRH3ALDH1A1KDM4EGAALMNA | |
| SCHEMBL3378936 | 0.83 | HRH3 (0.48) | HRH3ALDH1A1KDM4EL3MBTL1KMT2A | |
| SCHEMBL3377859 | 0.83 | HRH3 (0.44) | HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL3376760 | 0.83 | ALPL (0.44) | HRH3LMNAMAPTMEN1KMT2A | |
| SCHEMBL3377335 | 0.82 | HRH3 (0.48) | HRH3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |