SCHEMBL338037

SCHEMBL338037

Nc1nc(=O)c2nc(CN(c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)N(Cc3cnc4[nH]c(N)nc(=O)c4n3)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2[nH]1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 8/20 0.57
GART P22102 5/20 0.57
TYMS P04818 4/20 0.57
ATIC P31939 3/20 0.57
KDM4E B2RXH2 2/20 0.57
MEN1 O00255 2/20 0.57
ALDH1A1 P00352 2/20 0.57
POLB P06746 2/20 0.57
HPGD P15428 2/20 0.57
KMT2A Q03164 2/20 0.57
HSD17B10 Q99714 2/20 0.57
TDP1 Q9NUW8 2/20 0.57
GAA P10253 1/20 0.57
AKR1B1 P15121 1/20 0.57
TSHR P16473 1/20 0.57
PTGS2 P35354 1/20 0.57
TLR4 O00206 1/20 0.57
LMNA P02545 1/20 0.57
TP53 P04637 1/20 0.57
GLA P06280 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16583122 0.92 DHFR (0.57) DHFRGARTTYMSATICKDM4E
SCHEMBL20486467 0.92 DHFR (0.57) DHFRGARTTYMSATICKDM4E
SCHEMBL28344641 0.92 DHFR (0.57) DHFRGARTTYMSATICKDM4E
SCHEMBL28135233 0.92 DHFR (0.57) DHFRGARTTYMSATICKDM4E
SCHEMBL869876 0.92 DHFR (0.57) DHFRGARTTYMSATICKDM4E
SCHEMBL25167471 0.92 DHFR (0.57) DHFRGARTTYMSATICKDM4E
SCHEMBL3771709 0.91 DHFR (0.56) DHFRGARTTYMSATICKDM4E
SCHEMBL28885296 0.91 DHFR (0.56) DHFRGARTTYMSATICKDM4E
SCHEMBL15530423 0.91 DHFR (0.56) DHFRGARTTYMSATICKDM4E
SCHEMBL29133794 0.91 DHFR (0.56) DHFRGARTTYMSATICKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109601757-A A kind of feed addictive and complete feed quickly to become mildewed for guinea fowl 河南牧业经济学院 2019-04-12 CN claimed
US-20110217263-A1 EXPANSION OF HAEMOPOIETIC PRECURSORS MESOBLAST LIMITED (AU) 2011-09-08 US claimed
EP-2324109-A1 EXPANSION OF HAEMOPOIETIC PRECURSORS Angioblast Systems, Inc. (US) 2011-05-25 EP claimed
EP-2077844-A2 METHOD OF TREQATMENT AND COMPOSITIONS OF D-CHRIRO INOSITOL AND PHOSPHATES THEREOF Jennings-Spring, Barbara L. (US) 2009-07-15 EP claimed
WO-2008066634-A2 METHOD OF TREQATMENT AND COMPOSITIONS OF D-CHRIRO INOSITOL AND PHOSPHATES THEREOF JENNINGS-SPRING BARBARA L (US) 2008-06-05 WO claimed
WO-2024137455-A1 NANOPARTICULATE FORMULATION NEWIMMUNE II, LLC (US) 2024-06-27 WO disclosed
WO-2023010088-A1 NUTRACEUTICAL FORMULATIONS TO PREVENT, TREAT, AND INHIBIT EXCESS CYTOKINES, SARS-COV-2 SPIKE PROTEINS, AND MRNA VACCINE SPIKE PROTEINS PONO LIFESTYLE COLORADO, LLC (US) 2023-02-02 WO disclosed
CN-112552300-B Preparation method of 5-methyltetrahydrofolate hapten, antigen and monoclonal antibody 深圳泰乐德医疗有限公司 2022-01-18 CN disclosed
US-20210392897-A1 Topical Serum for Treating Damaged Plants COHN KALENE MARIE (US) 2021-12-23 US disclosed
US-11155816-B2 Oligonucleotide conjugates ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) 2021-10-26 US disclosed
US-20210238601-A1 Oligonucleotide Conjugates ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) 2021-08-05 US disclosed
CN-112961878-A Application of gene of lactobacillus plantarum in folic acid biological generation 昆明理工大学 2021-06-15 CN disclosed
WO-2008002470-A2 SIRNA SEQUENCES AGAINST BRF1 CALANDO PHARMACEUTICALS, INC. (US) 2008-01-03 WO disclosed
EP-1765089-A2 COMPOSITIONS COMPRISING EDIBLE OILS AND VITAMINS AND/OR MINERALS AND METHODS FOR MAKING THE COMPOSITIONS PBM Pharmaceuticals, Inc. (US) 2007-03-28 EP disclosed
US-20060188607-A1 Oral compositions comprising edible oils and vitamins and/or minerals and methods for making oral compositions PBM PHARMACEUTICALS, INC. 2006-08-24 US disclosed
WO-2005112654-A2 COMPOSITIONS COMPRISING EDIBLE OILS AND VITAMINS AND/OR MINERALS AND METHODS FOR MAKING THE COMPOSITIONS PBM PHARMACEUTICALS, INC. (US) 2005-12-01 WO disclosed
WO-2005094265-A2 SELF ASSEMBLING ACTIVATION AGENTS TARGETED USING ACTIVE DRUG RELEASE HEMOLYTICS, INC. (US) 2005-10-13 WO disclosed
EP-0951293-A4 METHOD FOR TREATING ALZHEIMER'S DISEASE BRISTOL MYERS SQUIBB CO (US) 2002-06-26 EP disclosed
EP-0951293-A1 METHOD FOR TREATING ALZHEIMER'S DISEASE BRISTOL-MYERS SQUIBB COMPANY (US) 1999-10-27 EP disclosed
WO-1998019690-A1 METHOD FOR TREATING ALZHEIMER'S DISEASE BRISTOL-MYERS SQUIBB COMPANY (US) 1998-05-14 WO disclosed