Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | FYN | P06241 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198806 | 0.90 | FLT3 (0.50) | KDRFYNFLT3 | |
| SCHEMBL3386386 | 0.85 | KDR (0.68) | KDRFYNFLT3CHEK1FGFR3 | |
| SCHEMBL14144050 | 0.81 | FLT3 (0.69) | KDRFLT3FGFR3 | |
| SCHEMBL3385052 | 0.81 | FLT3 (0.52) | KDRFYNFLT3FGFR3GABRG2 | |
| SCHEMBL112601 | 0.78 | PRMT6 (0.63) | PRMT6DRD2DRD4DRD3 | |
| SCHEMBL3197191 | 0.75 | FLT3 (0.51) | KDRFYNFLT3 | |
| SCHEMBL13336760 | 0.74 | KDR (0.73) | KDRFGFR3 | |
| SCHEMBL3385437 | 0.73 | KDR (0.69) | KDRFLT3FGFR3 | |
| SCHEMBL3379605 | 0.73 | KDR (0.67) | KDRFYNFLT3FGFR3GABRG2 | |
| SCHEMBL14144200 | 0.72 | KDR (0.75) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |