Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.53 |
| ▸ | CTSG | P08311 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10358851 | 1.00 | HTT (0.57) | HTTALDH1A1RAB9AHPGDCTRB1 | |
| SCHEMBL15146792 | 0.91 | HTT (0.68) | HTTALDH1A1RAB9AHPGDCTRB1 | |
| SCHEMBL6342085 | 0.89 | CTRB1 (0.59) | ALDH1A1RAB9AHPGDCTRB1CTSG | |
| SCHEMBL4730512 | 0.84 | KMT2A (0.64) | ALDH1A1RAB9ALMNAPOLB | |
| SCHEMBL23280913 | 0.84 | HTT (0.56) | HTTALDH1A1RAB9AHPGDCTRB1 | |
| SCHEMBL7223871 | 0.84 | TAS1R3 (0.63) | HTTALDH1A1RAB9AHPGDCTRB1 | |
| SCHEMBL12947869 | 0.84 | HTT (0.60) | HTTALDH1A1RAB9AHPGDHDAC4 | |
| SCHEMBL14079707 | 0.84 | HTT (0.60) | HTTALDH1A1RAB9AHPGDHDAC4 | |
| SCHEMBL11018467 | 0.84 | HTT (0.60) | HTTALDH1A1RAB9AHPGDCTRB1 | |
| SCHEMBL8805810 | 0.83 | MMP2 (0.56) | ALDH1A1RAB9AHPGDCTRB1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144393-A1 | 2-SUBSTITUTED 5-(PHENYL)-1,2-DIHYDRO-3H-3-BENZAZEPINE-3-CARBOXAMIDE DERIVATIVES AS BRD4 INHIBITORS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-08-31 | — | — | WO | disclosed |
| US-9447033-B2 | Potassium channel blockers | JAPAN TOBACCO INC. (JP) | 2016-09-20 | — | — | US | disclosed |
| US-20150259282-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2015-09-17 | — | — | US | disclosed |
| US-9073834-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2015-07-07 | — | — | US | disclosed |
| US-20140221337-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2014-08-07 | — | — | US | disclosed |
| US-8673901-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2014-03-18 | — | — | US | disclosed |
| US-20100087428-A1 | Novel Potassium Channel Blockers | XENTION LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
| US-5310911-A | Chiral synthesis for producing 1-azabicyclo(2.2.1)heptane-3-carboxylates | COTTRELL I F | 1994-05-10 | — | — | US | disclosed |
| US-5124460-A | Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes | MERCK SHARP & DOHME LTD. (GB) | 1992-06-23 | — | — | US | disclosed |
| US-5104989-A | Chiral synthesis for producing 1-azabicyclo[2.2.1] heptane-3-carboxylates | MERCK SHARP & DOHME LTD. (GB) | 1992-04-14 | — | — | US | disclosed |
| EP-0456310-A2 | Enantioselective synthesis of 3-substituted 1-azabicyclo [2.2.1]heptanes | MERCK SHARP & DOHME LTD. (GB) | 1991-11-13 | — | — | EP | disclosed |
| EP-0398616-A2 | Chiral synthesis for producing 1-azabicyclo[2.2.1]heptane-3-carboxylates | MERCK SHARP & DOHME LTD. (GB) | 1990-11-22 | — | — | EP | disclosed |
| EP-0398617-A2 | Process for resolving 1-azabicyclo [2.2.1]heptane-3-carboxylates | MERCK SHARP & DOHME LTD. (GB) | 1990-11-22 | — | — | EP | disclosed |
| US-3953512-A | Process for manufacturing 2-aminobutanol | POLSKA AKADEMIA NAUK INSTYTUT CHEMII ORGANICZNEJ (PO) | 1976-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221337-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | HTT 2305/4885ALDH1A1 1360/4885RAB9A 1923/4885 |
| US-20100087428-A1 | Novel Potassium Channel Blockers | HCN4, SCN2B, KCNH2 | HTT 2035/4885ALDH1A1 3795/4885RAB9A 3852/4885 |
| US-20150259282-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | HTT 2305/4885ALDH1A1 1360/4885RAB9A 1923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.