Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 12/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 10/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3195685 | 0.92 | KDR (0.54) | RETKDRFGFR3FLT3LMNA | |
| SCHEMBL3187562 | 0.89 | KDR (0.56) | KDRFGFR3EPHX2PTGS2 | |
| SCHEMBL3195980 | 0.88 | RET (0.60) | RETKDRFGFR3MEN1LMNA | |
| SCHEMBL3386132 | 0.88 | KDR (0.55) | KDRFGFR3FLT3MEN1LMNA | |
| SCHEMBL3186124 | 0.88 | MGLL (0.49) | KDRFGFR3FLT3EPHX2PTGS2 | |
| SCHEMBL3197817 | 0.88 | RET (0.56) | RETKDRFGFR3MEN1LMNA | |
| SCHEMBL27686821 | 0.88 | KDR (0.56) | KDRFGFR3 | |
| SCHEMBL3385413 | 0.87 | RORC (0.48) | RETKDRFGFR3FLT3MEN1 | |
| SCHEMBL3381307 | 0.87 | RET (0.54) | RETKDRFGFR3 | |
| SCHEMBL3385250 | 0.86 | FLT3 (0.47) | RETKDRFGFR3FLT3PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |