Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 7/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385476 | 0.89 | KDR (0.49) | FLT3DDR1KDRFGFR3CSF1R | |
| SCHEMBL3385413 | 0.86 | RORC (0.48) | FLT3RORCKDRFGFR3CSF1R | |
| SCHEMBL3383213 | 0.86 | RET (0.55) | FLT3KDRFGFR3RETPTGS2 | |
| SCHEMBL3185028 | 0.81 | BACE1 (0.49) | FLT3KDRFGFR3 | |
| SCHEMBL27705869 | 0.81 | KDR (0.49) | FLT3KDRFGFR3 | |
| SCHEMBL3385738 | 0.80 | FLT3 (0.49) | FLT3RORCKDRFGFR3 | |
| SCHEMBL3380684 | 0.79 | EPHX2 (0.53) | FLT3KDRFGFR3 | |
| SCHEMBL3195685 | 0.79 | KDR (0.54) | FLT3KDRFGFR3RET | |
| SCHEMBL3383453 | 0.77 | FLT3 (0.53) | FLT3KDRCSF1RNTRK1RET | |
| SCHEMBL3386505 | 0.77 | RET (0.65) | FLT3KDRCSF1RNTRK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |