Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 5/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386457 | 0.94 | DDR1 (0.42) | DDR1DDR2ABL1KITBCR | |
| SCHEMBL3385826 | 0.94 | DDR1 (0.48) | DDR1DDR2ABL1KITBCR | |
| SCHEMBL3384104 | 0.90 | FGFR3 (0.46) | DDR1DDR2ABL1KITBCR | |
| SCHEMBL3384523 | 0.88 | FGFR3 (0.46) | DDR1DDR2ABL1KITBCR | |
| SCHEMBL3385480 | 0.84 | KDR (0.48) | DDR1DDR2ABL1KITBCR | |
| SCHEMBL3385512 | 0.83 | FGFR3 (0.43) | DDR1DDR2ABL1KITBCR | |
| SCHEMBL3384506 | 0.83 | KDR (0.59) | DDR1DDR2ABL1KITBCR | |
| SCHEMBL3202028 | 0.82 | KDR (0.41) | RETKDRFGFR3 | |
| SCHEMBL3383762 | 0.80 | KDR (0.45) | DDR1RETKDRFGFR3 | |
| SCHEMBL3186574 | 0.80 | KDR (0.39) | RETKDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |