Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 9/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383251 | 0.88 | DDR1 (0.47) | FGFR3KDRRETDDR1DDR2 | |
| SCHEMBL3385512 | 0.87 | FGFR3 (0.43) | FGFR3KDRRETDDR1DDR2 | |
| SCHEMBL3385826 | 0.83 | DDR1 (0.48) | FGFR3KDRRETDDR1DDR2 | |
| SCHEMBL3384506 | 0.83 | KDR (0.59) | FGFR3KDRRETDDR1DDR2 | |
| SCHEMBL3184079 | 0.83 | FGFR3 (0.47) | FGFR3KDRRET | |
| SCHEMBL3386457 | 0.82 | DDR1 (0.42) | FGFR3KDRRETDDR1DDR2 | |
| SCHEMBL3197078 | 0.80 | FGFR3 (0.44) | FGFR3KDRRET | |
| SCHEMBL3385818 | 0.79 | KDR (0.49) | FGFR3KDRDDR1DDR2ABL1 | |
| SCHEMBL3384104 | 0.78 | FGFR3 (0.46) | FGFR3KDRRETDDR1DDR2 | |
| SCHEMBL3184828 | 0.78 | KDR (0.55) | FGFR3KDRDDR1DDR2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |