Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.47 |
| ▸ | KDR | P35968 | 8/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383467 | 0.93 | FLT3 (0.44) | FLT3KDRFGFR3 | |
| SCHEMBL3386223 | 0.92 | FLT3 (0.43) | FLT3KDRFGFR3 | |
| SCHEMBL3385035 | 0.90 | KDR (0.49) | FLT3KDRFGFR3ALDH1A1 | |
| SCHEMBL3385275 | 0.87 | KDR (0.51) | FLT3KDRFGFR3NTRK1CSF1R | |
| SCHEMBL3383429 | 0.85 | FLT3 (0.48) | FLT3KDRFGFR3NTRK1RET | |
| SCHEMBL3382113 | 0.85 | KDR (0.50) | FLT3KDRFGFR3 | |
| SCHEMBL3381951 | 0.85 | FLT3 (0.58) | FLT3KDRFGFR3 | |
| SCHEMBL3385590 | 0.84 | MAPK14 (0.40) | FLT3KDRFGFR3NTRK1ALDH1A1 | |
| SCHEMBL3383393 | 0.84 | FLT3 (0.47) | FLT3KDRFGFR3 | |
| SCHEMBL3386477 | 0.83 | KDR (0.47) | FLT3KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |