Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382710 | 0.90 | MAPK14 (0.60) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL3386198 | 0.89 | PTK2 (0.60) | MAPK14MAPK13MAPK11MAPK12 | |
| SCHEMBL3383429 | 0.88 | FLT3 (0.48) | MAPK14MAPK13MAPK11MAPK12FLT3 | |
| SCHEMBL3385541 | 0.85 | PTK2 (0.57) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL3383188 | 0.85 | FLT3 (0.48) | MAPK14FLT3NTRK1RETKDR | |
| SCHEMBL3384012 | 0.84 | KDR (0.53) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL3195720 | 0.84 | FLT3 (0.50) | FLT3KDR | |
| SCHEMBL3386448 | 0.82 | FLT3 (0.54) | MAPTFLT3KDRRAF1 | |
| SCHEMBL3383492 | 0.82 | FLT3 (0.50) | MAPK14FLT3NTRK1RETKDR | |
| SCHEMBL3176929 | 0.80 | FLT3 (0.45) | MAPK14MAPK13MAPK11MAPK12FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |