Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382710 | 0.87 | MAPK14 (0.60) | KDRFGFR3MAPK14MAPK13MAPK11 | |
| SCHEMBL3385541 | 0.86 | PTK2 (0.57) | KDRFGFR3MAPK14MAPK13MAPK11 | |
| SCHEMBL3383385 | 0.84 | MAPK14 (0.51) | KDRMAPK14MAPK13MAPK11MAPT | |
| SCHEMBL3380805 | 0.81 | FLT3 (0.57) | KDRFGFR3MAPK14MAPK13MAPK11 | |
| SCHEMBL3385883 | 0.76 | KDR (0.50) | KDRFGFR3MAPK14MAPK13MAPK11 | |
| SCHEMBL3385668 | 0.73 | RET (0.47) | KDRFGFR3MAPK14MAPK11NTRK1 | |
| SCHEMBL3386198 | 0.73 | PTK2 (0.60) | MAPK14MAPK13MAPK11MAPK12 | |
| SCHEMBL3383429 | 0.73 | FLT3 (0.48) | KDRFGFR3MAPK14MAPK13MAPK11 | |
| SCHEMBL18407354 | 0.73 | MAPK14 (0.81) | MAPK14MAPK13MAPK11MAPTMAPK12 | |
| SCHEMBL3384029 | 0.72 | KDR (0.56) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |