Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385924 | 0.89 | FLT3 (0.44) | FLT3KDRFGFR3MAPK14 | |
| SCHEMBL3383429 | 0.87 | FLT3 (0.48) | FLT3RETKDRFGFR3MAPK14 | |
| SCHEMBL3383385 | 0.85 | MAPK14 (0.51) | FLT3RETKDRMAPK14NTRK1 | |
| SCHEMBL3383407 | 0.85 | FLT3 (0.47) | FLT3KDRFGFR3 | |
| SCHEMBL3381104 | 0.83 | KDR (0.55) | FLT3RETKDRFGFR3NTRK1 | |
| SCHEMBL3385668 | 0.82 | RET (0.47) | RETKDRFGFR3MAPK14NTRK1 | |
| SCHEMBL27705869 | 0.81 | KDR (0.49) | FLT3KDRFGFR3 | |
| SCHEMBL3197333 | 0.81 | FLT3 (0.53) | FLT3KDR | |
| SCHEMBL3195685 | 0.79 | KDR (0.54) | FLT3RETKDRFGFR3 | |
| SCHEMBL3176929 | 0.79 | FLT3 (0.45) | FLT3KDRFGFR3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |