SCHEMBL3384640

SCHEMBL3384640

O=C(O)C(c1ccccc1)C(Cl)Cl

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.73
SRC P12931 2/20 0.52
LMNA P02545 5/20 0.50
MAPK1 P28482 1/20 0.50
KMT2A Q03164 1/20 0.48
TSHR P16473 1/20 0.46
HPGD P15428 1/20 0.46
CES2 O00748 2/20 0.43
CES1 P23141 2/20 0.43
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11315838 0.85 CYP2D6 (1.00) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL7815004 0.85 CYP2D6 (1.00) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL659768 0.85 CYP2D6 (1.00) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL7824857 0.85 CYP2D6 (1.00) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL12870188 0.84 CYP2D6 (0.56) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL27818755 0.82 CYP2D6 (0.94) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL11022387 0.82 CYP2D6 (0.54) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL11369030 0.79 CYP2D6 (0.77) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL29054565 0.79 CYP2D6 (0.61) CYP2D6SRCLMNAMAPK1KMT2A
SCHEMBL21939337 0.78 CYP2D6 (0.76) CYP2D6SRCLMNAMAPK1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116606206-A Preparation process of picoxystrobin intermediate methyl o-chloromethyl phenylacetate 河北诚信集团有限公司 2023-08-18 CN disclosed
CN-116606206-A Preparation process of picoxystrobin intermediate methyl o-chloromethyl phenylacetate 河北诚信集团有限公司 2023-08-18 CN disclosed
EP-1072580-B1 PROCESS FOR PRODUCING CHLOROMETHYLPHENYLACETIC ACID IHARA CHEMICAL IND CO (JP) 2010-12-01 EP disclosed
US-7491834-B2 Chemical process SYNGENTA CROP PROTECTION, INC. (US) 2009-02-17 US disclosed
US-20060163159-A1 Chemical process SYNGENTA CROP PROTECTION, INC. 2006-07-27 US disclosed
EP-1506184-A2 PROCESS FOR THE PREPARATION OF 3-ISOCHROMANONE Syngenta Limited (GB) 2005-02-16 EP disclosed
WO-2003095442-A2 PROCESS FOR THE PREPARATION OF 3-ISOCHROMANONE SYNGENTA LIMITED (GB) 2003-11-20 WO disclosed
US-6414186-B1 REACTING METHYLPHENYLACETIC ACID WITH CHLORINE GAS, IN INERT SOLVENT, UNDER IRRADIATION WITH LIGHT OR IN PRESENCE OF RADICAL INITIATOR IHARA CHEMICAL INDUSTRY CO., LTD. (JP) 2002-07-02 US disclosed
EP-1072580-A1 PROCESS FOR PRODUCING CHLOROMETHYLPHENYLACETIC ACID Ihara Nikkei Chemical Industry Co., Ltd. (JP) 2001-01-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060163159-A1 Chemical process HAO2, OGDH, TST CYP2D6 297/4885SRC 262/4885LMNA 4573/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.