Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11842565 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL499995 | 0.98 | ALDH1A1 (0.50) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL921218 | 0.92 | ALDH1A1 (0.48) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL270347 | 0.84 | — | — | |
| SCHEMBL23870571 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL774379 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL2606180 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL8165550 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL774780 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL775555 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTPOLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |