Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 13/20 | 0.34 |
| ▸ | KDR | P35968 | 13/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381856 | 0.90 | PIK3CA (0.45) | FGFR3KDRPIK3CAMTORFLT3 | |
| SCHEMBL3385155 | 0.84 | NPC1 (0.49) | MAPK13MAPK14NPC1RAB9AFLT3 | |
| SCHEMBL3385688 | 0.79 | PIK3CA (0.46) | FGFR3KDRPIK3CAMTORFLT3 | |
| SCHEMBL3381118 | 0.74 | NPC1 (0.54) | FGFR3KDRMAPK13MAPK14NPC1 | |
| SCHEMBL3383303 | 0.74 | NPC1 (0.52) | KDRMAPK13MAPK14NPC1RAB9A | |
| SCHEMBL3385839 | 0.73 | NPC1 (0.51) | KDRMAPK13MAPK14NPC1RAB9A | |
| SCHEMBL3381854 | 0.73 | NPC1 (0.49) | FGFR3KDRPIK3CAMTORMAPK13 | |
| SCHEMBL3383068 | 0.73 | NPC1 (0.50) | FGFR3KDRMAPK13MAPK14NPC1 | |
| SCHEMBL3381837 | 0.73 | NPC1 (0.48) | MAPK13MAPK14NPC1RAB9AFLT3 | |
| SCHEMBL3383147 | 0.72 | FGFR3 (0.40) | FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |