Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 10/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381856 | 0.90 | PIK3CA (0.45) | PIK3CAMTORKDRFGFR3FLT3 | |
| SCHEMBL3385682 | 0.83 | FLT3 (0.54) | PIK3CAMTORKDRFGFR3FLT3 | |
| SCHEMBL3385159 | 0.79 | FGFR3 (0.34) | PIK3CAMTORKDRFGFR3FLT3 | |
| SCHEMBL3383424 | 0.75 | FLT3 (0.45) | PIK3CAMTORKDRFGFR3FLT3 | |
| SCHEMBL3381854 | 0.74 | NPC1 (0.49) | PIK3CAMTORKDRFGFR3FLT3 | |
| SCHEMBL3385641 | 0.72 | FLT3 (0.45) | PIK3CAMTORKDRFGFR3FLT3 | |
| SCHEMBL3386414 | 0.72 | RAF1 (0.58) | KDRFGFR3FLT3RAF1 | |
| SCHEMBL3383492 | 0.72 | FLT3 (0.50) | KDRFLT3NTRK1RAF1 | |
| SCHEMBL3385308 | 0.71 | KDR (0.41) | PIK3CAMTORKDRFGFR3RAF1 | |
| SCHEMBL3385510 | 0.71 | MAPK14 (0.48) | KDRFLT3RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |