Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385268 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2CA2CA1CA12CA9 | |
| SCHEMBL1710544 | 0.84 | CA1 (0.38) | SMN1; SMN2CA2CA1HDAC3HDAC4 | |
| SCHEMBL1710540 | 0.84 | CA1 (0.38) | SMN1; SMN2CA2CA1HDAC3HDAC4 | |
| SCHEMBL1710542 | 0.82 | SMN1; SMN2 (0.38) | SMN1; SMN2CA2CA1HDAC3HDAC4 | |
| SCHEMBL3387791 | 0.81 | KMT2A (0.47) | CA2CA1CA12CA9HDAC3 | |
| SCHEMBL3387796 | 0.81 | KMT2A (0.47) | CA2CA1CA12CA9HDAC3 | |
| SCHEMBL3388394 | 0.79 | CTSL (0.38) | SMN1; SMN2CA2CA1HDAC3HDAC4 | |
| SCHEMBL3388391 | 0.79 | CTSL (0.38) | SMN1; SMN2CA2CA1HDAC3HDAC4 | |
| SCHEMBL3385280 | 0.79 | CA1 (0.33) | SMN1; SMN2CA2CA1HDAC3HDAC4 | |
| SCHEMBL3385272 | 0.79 | CA1 (0.33) | SMN1; SMN2CA2CA1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093865-A1 | SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093865-A1 | SULPHUR-LINKED COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ALDH1A2, MPST, CLN6 | SMN1; SMN2 129/4885CA2 1943/4885CA1 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.