Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383188 | 0.89 | FLT3 (0.48) | FLT3MAPK14FGFR3KDR | |
| SCHEMBL3385711 | 0.88 | MAPK14 (0.51) | FLT3PTK2CDK8MAPK14CYP2C9 | |
| SCHEMBL3386198 | 0.86 | PTK2 (0.60) | PTK2MAPK14CYP2C9CYP2D6CYP2C8 | |
| SCHEMBL3383407 | 0.81 | FLT3 (0.47) | FLT3FGFR3KDR | |
| SCHEMBL3381104 | 0.79 | KDR (0.55) | FLT3FGFR3KDR | |
| SCHEMBL27705869 | 0.78 | KDR (0.49) | FLT3FGFR3KDR | |
| SCHEMBL31386838 | 0.77 | FLT3 (0.58) | FLT3PTK2MAPK14PTGS2CYP2C9 | |
| SCHEMBL3197333 | 0.77 | FLT3 (0.53) | FLT3KDR | |
| SCHEMBL3383429 | 0.77 | FLT3 (0.48) | FLT3MAPK14FGFR3KDRMAPK13 | |
| SCHEMBL3196311 | 0.76 | MAPK14 (0.50) | PTK2CDK8MAPK14CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |