Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 15/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 14/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3187562 | 0.86 | KDR (0.56) | EPHX2PTGS2KDRFGFR3 | |
| SCHEMBL3386132 | 0.83 | KDR (0.55) | EPHX2PTGS2KDRFGFR3 | |
| SCHEMBL3192647 | 0.80 | FLT3 (0.48) | KDRFGFR3 | |
| SCHEMBL3385968 | 0.79 | FGFR3 (0.53) | KDRFGFR3 | |
| SCHEMBL3383213 | 0.78 | RET (0.55) | EPHX2PTGS2KDRFGFR3 | |
| SCHEMBL3380684 | 0.78 | EPHX2 (0.53) | EPHX2KDRFGFR3 | |
| SCHEMBL3320104 | 0.77 | FGFR3 (0.79) | KDRFGFR3 | |
| SCHEMBL3195685 | 0.77 | KDR (0.54) | KDRFGFR3 | |
| SCHEMBL3383984 | 0.77 | KDR (0.68) | KDRFGFR3 | |
| SCHEMBL3186124 | 0.77 | MGLL (0.49) | EPHX2PTGS2KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |